THORNE - Phosphatidylserine (Formerly Iso-Phos) - Cortisol Management Support - Phosphatidylserine Isolate Supplement to Support Brain Function* - 60 Capsules - 60 Servings

I started using Thorne’s Phosphatidylserine in June 2025, and I’ve now tested it in both calm and high-stress situations. Each time, the effects were consistent and noticeable. This isn’t a sedative and it doesn’t leave you groggy. What it does is take the edge off your nervous system. For me, it showed up as a subtle but powerful calm—enough to quiet racing thoughts so I could process, rest, or simply breathe. The shift is clear without feeling “drugged” or detached. I took it once during the day, and once at night and then again at night following the shocking news of Charlie Kirk’s assassination. Both night times, my baseline was hypervigilance—restless body, mind in overdrive. Within about 30–45 minutes, I could feel my system regulate. It didn’t put me in a trance, but it gave me the mental space to think clearly and relax. Interestingly, when it wore off at night, I woke up and immediately felt my mind racing again, which confirmed to me just how effective it had been while active. Another strength: no hangover effect the next morning. Unlike some calming supplements that leave you foggy, this one leaves you steady and clear. Yes, it’s on the expensive side—but when a product actually does what the science says it should, that value is there. Phosphatidylserine has been studied for its role in cortisol regulation and cognitive resilience- That's something I have looked into, and I can say firsthand: Thorne delivers on that research. I do buy other Thorne products because I value their research and quality (but I have to say it is very expensive to be a fan of Thorne) For anyone dealing with stress, overactive thoughts, or the need to stay clear while calming down, this is worth having in your toolbox. I have recommended it twice to people since this tragic news and loss of life of a well known God fearing public figure.

Thank you

Basically I hadn't slept in 30 years. I can count on one hand the number of good nights sleep in the past. Tried to sleep at night but always had a wired feeling after 6pm. Long story short, it turns out that I had high cortisol levels at night which kept me awake causing insomnia. Phosphatidylserine reduces cortisol levels and has allowed me to actually sleep for the first time in my life! I take 2 capsules three hours before bedtime then two more capsules one hour before bedtime. I also have restless legs at night which is a secondary problem that wakes me up during the night. Stretching helps a lot, but that, along with Thornes magnesium bisglycinate powder gets rid of it. One scoop an hour before bedtime and if I wake during the night I take another scoop. Remember that insomnia is just a "symptom" to an underlying cause. Treating symptoms is futile, more often than not most symptoms are your body's reaction to a root problem. I also do one 3mg. chewable melatonin before bed as well.

Great product keep ordering it

Delivered on time. Thanks

I had mixed results with Phosphatidylserine and cannot give it 5 stars. I took it (1 capsule per evening) for one week and wanted to do a longer trial but one side effect stopped me. I noticed that I became slightly agitated and felt a bit depressed after taking it each day (I felt fine several hours later). The 'something is not okay' feeling was off putting. The bottle is stowed away for a while. I will try taking it again in a couple weeks to see if I have the same reaction. I have noticed that my general mood seems lighter, which could be from taking this supplement, but won't know until I try it again.

I have confidence in Thorne products. Although they tend to be more expensive than other products, they seem to be well produced, and I feel confident taking them. Supplements seem to be articles of faith. After all, I am taking them and spending money hoping that they work. Therefore, they work. This product must be working; I remembered to write a review.

Good product