NOW Foods Supplements, SAMe (S-Adenosyl-L-Methionine) 400 mg, Nervous System Support*, 30 Tablets

This is one of few that doesn’t irritate my stomach. It certainly is a mood enhancer and helps with fibromyalgia pain. I’m so disappointed it’s been out of stock for months.

I've seen this item pop up in several health articles lately about being good for joint swelling and I feel it's working for me. I've taken it daily for a few weeks now and I feel a little more flex in my fingers.

You will see many reviews from me concerning Now Foods vitamins and minerals. I have come to completely trust this company in their production of a pure and safe product. I know if it comes from Now Foods that I will not have to worry about a contaminated product, or a product that is not the strength stated on the label. This winter has been very stressful for me, so at the suggestion of my brother I used this and found a measurable difference in two days and after 7 days felt almost back to normal.

A little research on the internet tells you about some over-the-counter vitamins or alternative medicines for a variety of conditions. This is a great company and dose to get started taking SAM-e with approval from your doctor.If you are taking it for symptoms of depression, you might notice a difference, like a general mood lift. If you are bipolar, do NOT take this without doctor approval!Altogether, my experience with the product itself was positive, but it was not an effective treatment for me. I am giving it 3 stars because purchasing this and taking it without doctor recommendation is really not a good idea. There can be some negative side-effects, and it’s not worth the trouble unless it is really helping.

So far, after 3 weeks, I like this supplement. As a person who suffers from SAD for years now, I am looking for more 'help'. I use a lightbox every winter. It helps, but sometimes it just isn't enough. I sometimes use Reishi, Cordyceps - both which have their strengths and I recommend, but would really like to replace my lightbox if I could. I cut my lightbox time in 1/2, down to 15 min tjhis past week, so far so good, will let you know if that doesn't work out.I have also suffered from depression in the past, was treated, but that's when SAD was uncovered. SAMe seems to boost my mood, my mental and physical energy levels and take the edge off my appetite (I crave CARBS during the winter, just want to eat, sigh!) I also noticed I slump less, want to walk straighter, more interested in losing weight, exercising, and has greatly diminished my back ache as well as other aches that came with going through the change.I started with one whole pill, but that was too much. (sort of jittery or perhaps a bit manic, just felt like too much) So I cut back to 1/4 pill 2x's/day, starting about 8am, second around 2pm. Then I went to 1/3 of a pill 2x's/day. That is where I am at now, not sure if I will go to 1/2 or not. Lowest dose that works is good for me. Also, UofMD says if you are low in Vit B12 or folate, you will be low in SAMe also, and they work together (google SAMe and Vit B, should be first link - very informative article including interactions - do NOT use WITH antidepressants! So I do 500 mcg of B12 (smallest dose I could find) later in the AM, along with Vit D (2000IUs) and Fish oil. I also have 1 - 2 cups of coffee in the AM. I am including this information so you have a more complete picture of what is working together here. (The Fish Oil is for my dry eyes)Sometimes this combo is a bit much, and some of you may agree it is. I'm still fine-tuning things here. But so far, this has definitely improved my winter life. No longer just surviving the day, but actually think I can get out to the gym, work on my home more, be better organized, and actually survive a trip to Florida soon. (You may think that's funny, but when you have SAD bad enough, you just don't want to do ANYTHING or go anywhere) Hope this helps you make a more informed decision. YMMV

I have used Now Sames for a while. I love that there are no fake sugars or additives that provoke migraines. I will continue to use this supplement for a clear mind (stops my overthinking and scatter brained-ness) and for joint health.

There are many Sam-e products available for purchase, but NOW brand is the only one I've found that does NOT use Titanium Dioxide as a filler. Since I believe the growing evidence that Titanium Dioxide is a contributing factor in gastro-intestinal disease such as bloating and Inflammatory Bowel Disease, I do NOT want to ingest Titanium Dioxide in anything I consume -- especially since it's only used as a useless filler or whitener and has no nutritional reason to be in anything.

I took these for two months, and wasn't sure if it was actually doing anything for my mood. I felt about the same mood wise, but in a weird bonus it helped with my knee and shoulder pain. Im not sure if thats normal or not, but after I ran out the pain returned. So I'm ordering some more.