Nature's Trove SAM-e 400mg 30 Enteric Coated Caplets. Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Support - Cold Form Blister Packed.

SAMe, S-adenyl L Methionine has been noted by research to improve cartilage formation. As you see from the name, it is essentially an amino acid. I purchased the 200 and 400 mg quantities. The product is a molecule that is synthesized by some yeasts - bakers' yeast is most common. While I cannot personally double-blind test its effectiveness, scientific evaluation has, and has shown it to increase cartilage recovery. I nearly completely re-tore a long-previously reconstructed knee , and, as my other knee had also been damaged by significant aerial mistakes and landings I sought more than just the usual chondroitin, MSM, etc. Having seen live images of the cartilage damage in my knees, and exploring the research, I strongly feel that SAMe is worth purchase. This brand is naturally-sourced - a good selling point, and it is reasonably priced on comparison to many others. SAMe is also sold as neuroactive, due to its part in the synthesis of serotonin, which was a matter of concern. Serotonin is synthesized through the production and synthesis of this molecule, in great part by mutualist symbiotic enteric microorganisms. Again, because this is natural, it is almost certainly a good nutritional supplement, as enteric organisms tend to change quickly in response to different dietary intake. Thus, it promotes more regular synthesis of one of the most important neurotransmitters. Due to the highly stressful period in which all of us are immersed, I haven't looked deeper into that neurological issue, although we DO know a few things about it. Serotonin itself cannot cross into the brain, and that produced in the intestines affects other physiological processes - we need it. But excess serotonin production in the brain affects males and females differently and the brain's feedback processes tend to act to restore normality (it's possible that some individuals may experience persistent insufficiency OR excess, but those are a small minority. .If you suspect such long-term problem, do consult a medical therapist - Psychologists can refer those with metabolic problems of persistent types to psychiatrists who can test for such problems. But recognize that serotonin understanding is in its infancy, and the past with its SSRIs and other quite invasive drugging, is like using a hammer to fix a computer board or a brain) That, in short, is why I do NOT recommend that people seek neurotropic drugs - from alcohol to other drugs, we interfere with or destroy natural functioning, which it's sometimes better to address ONLY through physical, mental, social activities. SAMe is, though, pretty much methionine, a food, and we may often be deficient in that amino acid - which is why it can improve cartilage formation, as well as other variables like digestion. So, explore the effects of ANYTHING you ingest, and DO NOT just take things because of inane claims unsupported by rigorous scientific research. This company was extremely responsive (FAST!) to my Amazon order, and, so, with its component sourcing, seems a great place from which to purchase nutritional products. While I have experienced reduced pain , I had also been expanding the exercise of joints I injured and reinjured, and so cannot honestly evaluate sensations like pain reduction for others. I use less aspirin since the combination of SAMe, the natural healing process, and slow increase of exercise of affected joints, and as usual recommend any safe reduction of NSAID use. SAMe does not have the deleterious side effects of NSAIDs.

Great effective product. The better SAM-E than other products. Cost is worth it.

I have been taking Nature's Trove SAM-e for quite a while now. I have found it to be a good supplement. I seem to feel more cheerful with it and SAM-e is supposed to have other benefits too. It's supposed help reduce pain, improve joint function, and be good for the liver, along with other benefits. This seems to be a good brand. It is always well packaged and the capsules are easy to swallow. All in all, a good supplement.

I've been taking these for over a month and I have to say they work phenomenally. Yah has blessed me with this product. I have had depression and anxiety for 10 years. I have tried herbal teas, sound therapy, CBD, lemon balm and other herbs and supplements. Nothing and I MEAN NOTHING works like SAM-E. I've tried the genius joy brand but it's low quality and over priced. I always like to do my own personal research before I take a substance. I found that taking 800 mg to 1600 mg for depression and anxiety is the optimal dose. I tried 800 mg the first 3 days and felt that wasn't enough. So I bumped it to 1600 mg a day and it's been working amazing ever since. That is 2 pills in the morning and 2 pills in the evening. Now I'm not going to lie to you.SAM-E is harsh on the stomach but after me and my mom prayed to Yah for a solution because O didnt want to go back to taking CBD because it's not as effective as SAM-E, we were given the solutions of taking it early in the morning (further first dose), I like to take it at 4 am and then go back to sleep b4 I have to get up for work or school. And then when I'm up and moving I will EAT ONE CHOBANI YOGURT. Theflavprs that have been effectived are BLACK CHERRY, KEY LIME, SMORES, & MIXED BERRY. I am confident that any of their flavors will work for people though, it's because of the probiotics. For the evening dose I just take it b4 dinner and I am good to go. Once I started incorporating the yogurt and taking the first dose early the loose stools and stomach cramps stopped. I was literally pooping 6 to 8 times a day. Based on my personal experience the CHOBANI YOGURT is protective for the stomach. And I'm not sure on why taking it early helps but I highly recommend taking it rhat way instead 30 minutes before you have to leave because you will have to poop on a public bathroom, I'm just being honest like how I want others to be with me. In conclusion if you don't have bipolar or are taking a current anti depressant give this a shot. But if you do HAVE BIPOLAR STAY AWAY BECAUSE THIS WILL GIVE YOU MANIA, the box states this and research online says this as well. Also if you're taking an antidepressant it could have a negative reaction with the SAM-E. be safe everyone, I want all of us that suffer from depression/ anxiety to feel better and live happy- healthy lives. I no longer have suicidal thoughts and I'm less anxious and depressed. I truly have seen a change in my life. And I want you to see a change in your life too. ❤

Seems ok

I have these shipped to me regularly. Keep my depression at bay. I've been taking them for years. Have recommended to others and they work for everyone

I used to be really depressed. I'm not just being flip ... I've been seeing a psychiatrist for about a decade, more off than on in the past two years. I was super depressed. I decided to NOT take anti-depression meds because I wanted to be sure what I was feeling was authentic and because I had tried them in the past unsuccessfully. Through a lot of hard work and patience from my family, friends and doctor, I don't have a diagnosis of depression anymore. I'm a very happy person now! Having said all that LOL ... I still suffer from Seasonal Affective Disorder (SAD) in the winter. I live in a very cloudy city and used to live in a very sunny city. A couple three years ago, I was mentioning this to an older woman and she said "I can help but you have to hear me out." Of course, I was intrigued. She told me about SAMe. I asked her how she found out and she said "A shaman told me." Okay. This person is the LEAST likely person to go see a shaman for anything anywhere but she had run into one on a vacation and he told her to try it. She figured what did she have to lose? Your blues, that's what. So, I got a pack of SAMe, not this brand, kept it in my car and took one every day on my way to work. One day, out of no where, I was like hey, I feel good. GOOD!! I continue to take them until summer rolled around. Once the days start getting shorter, I start taking them again. Since then, they have gone up in price substantially all over. And then you also run the risk of not getting the dosage you need or getting something that upsets your stomach or whatever. So far, I haven't had any trouble with this brand. I feel good. I feel mentally even-keeled, it does seem to help my ever-present joint pain and I just feel BETTER overall when I take SAMe. I have recommended it to many friends and will continue to do so. I was worried about this brand because I read so many people got upset stomachs. I've been fine and my stomach gets upset if I take OTC pain relievers. These are not the magic pill. You can't just take one and everything will be okay. For some people I've talked to, it takes a month or two. For me, it took about a month to really feel the effects the first time. Once I got on my seasonal rotation, it seems to take less time to even out from the SAD effects. The instructions on this pack suggest one a day but say some people might find another one a day beneficial. This is inline with what other brands suggest. I've never had to take more than one a day. There is a warning not to take these if you are bi-polar or maniac depressive or if you are taking prescription anti-depressants. This is something you should talk to your doctor about. There are some side effects, you can find them by doing a web search, but they are rare. YMMV of course. The price on these is VERY reasonable. This is a three-month supply. Unless you have to up the dosage for the first month or two ... It's one thing to give five stars to a sweater or some a kitchen gadget or something but when it comes to something that goes in your body, I think it's important to know if other people have had success. I have had success with this product. I'm going to look to see if I can put it on subscribe and save. It sits by my computer and I take one every morning with my coffee. Sometimes I eat right away, other days I don't. No tummy issues :)

Used for years and I find my joints don't bother me as much.