Doctor's Best SAM-e Mood & Joint Support & Liver Health (Pharmaceutical Grade/Non-GMO/Gluten Free/Vegetarian), Tablet, 60 Count (Pack of 1)

After only a couple of days of taking, these make me feel very ill. They make me go very pale in colour (to the point people are telling me I look pale), and not so Much a headache, but a heavy feeling down one side of my head. I wanted them for Joint support but I will pass…

SAMe was a recommended supplement in Dr. Daniel Amen's book, "Making a Good Brain Great". There is a section in the brain, called the Deep Limbic System (DLS) and when it is not functioning right (excessive activity in this part of the brain), these problems can occur: depression, sadness, focusing on the negative, irritability, low motivation and energy, negativity, social disconnection/isolation, low self-esteem, crying spells, feelings of hopelessness or worthlessness. I was experiencing all of these. Some days I would be fine and other days I felt like I was losing my mind. I had absolutely nothing to be depressed/sad about and the littlest things would bother me and/or make me upset. I was also very irritable. It was getting out of control and it was really affecting my life and my relationship with my boyfriend. I am not too keen on taking any type of pill, which is why I avoided going to see a doctor. I knew he/she would only prescribe me anti-depressants of some sort, which are not only expensive, but also have many negative side effects. This is when I decided to give SAMe a try - and it has changed my life like I never thought possible. It improved my mood and my motivation. I am not nearly as negative and irritable as I was before and I feel really good about my life and in general. For the women out there, I also noticed an improvement in my PMS symptoms. A few things to take note of: -Check with your doctor first before taking. I didn't, but you really should. -Start off with a lower dose. I first started with 400mg and after a few days I started getting anxiety and also a headache shortly after taking. The better dose for me is 200mg, but everyone is different. -Take a vitamin B supplement with SAMe. More specifically, B12, B6 and Folate. This helps with absorbency. -DO NOT take if you have bipolar disorder or are taking other anti-depressants. SAMe is best taken on an empty stomach. Wait 30 minutes or so before eating. I take mine in the morning, along with a vitamin B complex and it has worked out very well. Also be sure to give it time to work. I saw the most improvement after 2 weeks of daily usage. Hope this helps :-)

I’ve suffered from depression since I was 11. I am now 34. I was prescribed an Antidepressant in my twenties and I didn’t like the effect it had on me. I’ve always fought this on my own and tried different methods but I could not stay consistent due to my frequent breakdowns and mood changes. My coworker show this to me and I went ahead and gave it a try and I absolutely love it. I can’t explain the change in my moods, it’s like I’m more clear and can enjoy being happy longer with simple things. My thoughts aren’t spiraling out of control..I can control my emotions more . I am able to get things done instead of finding a way to lay in bed or distant myself. It’s truly amazing. I’m telling more people about this. It truly has made a difference in my life and others. The only down side to this is it does cause diarrhea lol but honestly I’d take diarrhea over depression any day. I’m now just looking into a probiotic lol ***also it’s not just the supplement that going to change you, basically it has stabilized me to where I can do things to better myself and strengthen myself mentally. If you are taking this for depression you can’t just depend on a pill you have to go out and take action. Utilize it to tackle your challenges goals and new positive habits. I hope It does good to you how it has done for me. <3

Love it. And it helps tremendously with my autism, and my lyme disease. My only hang up and it's not that important. Is the last two orders that I've made have come in the old boxes instead of the new ones. I don't know if the new boxes or a temporary branding thing and they realize they weren't selling as much or what, or maybe they have old boxes left behind and they're just using them while they still can but it's all the same product with all the same ingredients so I'm not concerned

This stuff can work great, but keep in mind everyone is different and not everyone should be taking SAMe. It was so strong for me that I was only taking 50mg a day. I had to use a pill cutter and tightly wrap each piece in plastic wrap and use the 4 pieces within 4 days otherwise it broke down too fast. It gets glossy looking or gooey when bad. One thing people don't understand about SAMe is that it will increase your estrogen or play on your estrogen receptors. I think that is part of the reason it can work on depression, because increased estrogen also increases your brain chemicals serotonin and dopamine. But here's the tricky part: It only increases your estrogen by increasing your methylation process. I am so sensitive that I can tell small changes that happen to my body. I have had a hysterectomy and am on hormone pellets estradiol and testosterone. In the beginning of my pellets they come on strong and SAMe causes "too much" of the already too much hormones. At the end of the 3 month pellet dosing I am feeling low in hormones and the SAMe can sometimes help get me through by increasing my estrogens. The only thing is that flip flopping your neurotransmitters around by stopping and starting can be more of a shock than it's worth. I have felt euforia and I have felt anxiety and paranoia while on SAMe. I am one of those people who have tons of homozygous methylation dna problems and the bad COMT estrogen metabolism snp's. Just be careful and pay attention to how you are feeling. If your boobs swell up and you get anxiety while on it, that probably means you are overmethylating and getting too much estrogen in an already estrogen dominant body. Maybe you need Methyl folate and Methyl B12 and progesterone instead.

Starting on the smaller dose is great for those who respond well to meds (ie - get side effects from Rx's and want to try something that's easier on the body!). You can take 2, decide if 400 per dose is really for you or not. 200 is fine for many. This is a great price and if you take one a day, the box will last 2 months. The foil packs inside are not labeled, are compact (about a 4x6 picture size), and easy to pack in your purse side-pocket or briefcase for travel. The tablets push out easily, and cleanly. Best I have found, and being a Euro mfr is a plus in my mind. They are experts with Sam-e, as it's been dosed and studied very extensively there. Minor and passing side effects may include soft stool, but the body can usually adjust to that, esp. at 200 dosing.