---
product_id: 3558979
title: "Doctor's Best SAM-e Double Strength Supplement, 60 Enteric Coated Tablets"
brand: "doctor's best"
price: "€ 93.54"
currency: EUR
in_stock: true
url: https://www.desertcart.de/products/3558979-doctors-best-sam-e-double-strength-supplement-60-enteric-coated
store_origin: DE
region: Germany
---

# Non-GMO, vegan & gluten free enteric coated for max absorption 400mg potent SAM-e dose Doctor's Best SAM-e Double Strength Supplement, 60 Enteric Coated Tablets

**Brand:** doctor's best
**Price:** € 93.54
**Availability:** ✅ In Stock

## Summary

> 💥 Elevate your mind, move with ease, and detox like a pro!

## Quick Answers

- **What is this?** Doctor's Best SAM-e Double Strength Supplement, 60 Enteric Coated Tablets by doctor's best
- **How much does it cost?** € 93.54 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.de](https://www.desertcart.de/products/3558979-doctors-best-sam-e-double-strength-supplement-60-enteric-coated)

## Best For

- doctor's best enthusiasts

## Why This Product

- Trusted doctor's best brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Clean & Conscious:** Pharmaceutical grade, vegan, gluten-free, and Non-GMO—perfect for mindful wellness warriors.
- • **Liver Detox Dynamo:** Promotes liver health and detoxification, helping your body stay clean and energized.
- • **Mood & Mind Mastery:** Clinically backed SAM-e boosts dopamine, serotonin & norepinephrine for sharper focus and elevated mood.
- • **Joint Joy & Mobility:** Double strength formula supports comfortable movement and joint health, keeping you active and agile.
- • **Precision Absorption:** Enteric coating ensures SAM-e bypasses stomach acid for superior bioavailability and gentle digestion.

## Overview

Doctor's Best SAM-e Double Strength delivers 400mg of clinically studied SAM-e per enteric coated tablet, designed for optimal absorption and gastrointestinal comfort. This pharmaceutical-grade, vegan, Non-GMO supplement supports mood enhancement, cognitive health, joint comfort, mobility, and liver detoxification, backed by over 40 years of research and 18 controlled human trials.

## Description

What are the benefits of Doctor’s Best SAM-e Double Strength?
This formula helps support emotional well-being, cognitive function, joint comfort, mobility, and liver health as part of overall wellness support.*
Why are the tablets enteric coated?
The enteric coating is designed to help protect SAM-e through the stomach and support targeted release for improved absorption and gastrointestinal tolerance.*
Should I take with food or on an empty stomach?
Doctor’s Best recommends taking ONE enteric coated tablet daily between meals on an empty stomach for optimal absorption. Do not chew or crush the tablet.
What's the daily dosage?
Adults should take ONE 400 mg enteric coated tablet daily, or as recommended by a nutritionally informed physician.
Is Doctor’s Best SAM-e Double Strength vegetarian?
Yes. Doctor’s Best SAM-e Double Strength is Non-GMO, Gluten Free, Soy Free, and Vegetarian.
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## Features

- Doctor's Best SAMe Double Strength is proven to enhance mood and promote cognitive health
- SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine
- SAMe has been proven to promote joint comfort and mobility and supports liver health and detoxification
- SAMe's effectiveness has been proven with 18 controlled human trials published over 40 years
- Pharmaceutical grade, Non-GMO, Gluten Free, Vegan

## Technical Specifications

| Specification | Value |
|---------------|-------|
| Asin | B004YLAXOE |
| Date First Available | April 29, 2011 |
| Item Model Number | DRB-00252 |
| Manufacturer | Doctor’s Best, Inc |
| Product Dimensions | 3.25 x 2 x 6.13 inches; 3.2 ounces |

## Product Details

- **Brand:** Doctor's BEST
- **Diet Type:** Gluten Free, Vegan
- **Flavor:** Unflavored
- **Item Form:** Tablet
- **Item Weight:** 3.2 ounces
- **Item dimensions L x W x H:** 3.25 x 2 x 6.13 inches
- **Primary Supplement Type:** multivitamin
- **Product Benefits:** Detoxing
- **Special Ingredients:** Amino Acid
- **Unit Count:** 60 Count

## Images

![Doctor's Best SAM-e Double Strength Supplement, 60 Enteric Coated Tablets - Image 1](https://m.media-amazon.com/images/I/61qTxsnqhPL.jpg)
![Doctor's Best SAM-e Double Strength Supplement, 60 Enteric Coated Tablets - Image 2](https://m.media-amazon.com/images/I/61kdV1U4GrL.jpg)
![Doctor's Best SAM-e Double Strength Supplement, 60 Enteric Coated Tablets - Image 3](https://m.media-amazon.com/images/I/61fX5wRIN-L.jpg)
![Doctor's Best SAM-e Double Strength Supplement, 60 Enteric Coated Tablets - Image 4](https://m.media-amazon.com/images/I/71Y6lhiRc4L.jpg)
![Doctor's Best SAM-e Double Strength Supplement, 60 Enteric Coated Tablets - Image 5](https://m.media-amazon.com/images/I/81rqFIEdSjL.jpg)

## Available Options

This product comes in different **Flavor Name, Size** options.

## Questions & Answers

**Q: Is each tablet packaged in foil?**
A: The tablets are in a ten count foil blister pack. Each pill has it's own sealed compartment. I am an RN and this is like medical grade packaging. Safe.

**Q: Could this cause you to feel warm or hot and sometimes dizziness?**
A: SAM-e, especially when combined with other medications, has a potential to contribute to Seratonin Syndrome, which can cause temperature disregulation and dizziness. This is a supplement that effects the function of your brain and neural pathways. Please make sure you use it as directed and preferrably under the care of someone who is knowledgeable on the subject if you have not done your own research. If any adverse reactions occur, stop taking the supplement and please talk to your doctor about it. There is the potential for very bad reactions if Seratonin builds up too much. 

Every person's brain is unique and will react in different ways. Nothing involved in brain support supplements are a one-size-fits-all.

**Q: how long does it take to start working**
A: I have taken SAM-e for 15 years very successfully. It has never failed to work for me, unlike Rx antidepressants and other supplements (like St John's Wort). In the last year I have increased from 1 400 mg pill daily to 2. I'm in my 60s and i just seem to feel better with more. (It is also anti-aging because it helps correct the mistakes that accumulate in our DNA). In my experience SAM-e works very quickly. If I need a boost, I take an extra dose and I feel better within 1-2 hours. You can take up to 1600 mg in a day (four 400 mg pills) with no problem. If I know I'm going to have a stressful day I will head off problems by taking 2 upon awakening, and then 1-2 more later in the day, when I can be sure of an empty stomach. It's important to take SAM-e at least 30 minutes before food, or 2 hours after, for best absorption.

**Q: How do these compare to nature made? That's my usual.**
A: For me, I like Nature Made so much better. Nature Made worked for my husband and I. We switched to these in an effort to save money and within two weeks of the switch we both started hurting again. Also these came with several of the bubbles punctured and the pills were different colors, within the pack. If you read some of the recent reviews, you’ll see others had some of the same issues and far as punctured blister packs and color changes within the box. We switched back to Nature Made, which was the brand our Orthapedic doctor had recommended.

## Frequently Bought Together

- Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets
- Doctor's Best SAM-e Mood & Joint Support & Liver Health (Pharmaceutical Grade/Non-GMO/Gluten Free/Vegetarian), Tablet, 60 Count (Pack of 1)
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*Product available on Desertcart Germany*
*Store origin: DE*
*Last updated: 2026-09-12*