

🛑 Stop the itch, start the comfort — your skin’s new best friend!
E45 Itch Relief Cream is a dermatologist-formulated, dual-action treatment designed to soothe itching and irritation caused by eczema, dermatitis, and dry skin conditions. Featuring lauromacrogols for fast anti-itch relief and urea for deep moisturization, this lightweight, non-greasy cream comes in a generous 500g jar, making it ideal for sustained use. Highly rated by thousands, it’s a trusted solution for dry, itchy skin that fits seamlessly into your busy lifestyle.
| ASIN | B001EJOHUU |
| Active Ingredients | Allergy screened |
| Age Range (Description) | Kid |
| Age Range Description | Kid |
| Best Sellers Rank | #190,213 in Health & Household ( See Top 100 in Health & Household ) #317 in Itching & Rash Treatments #580 in Eczema, Psoriasis & Rosacea Care |
| Brand | E45 |
| Brand Name | E45 |
| Container Type | Jar |
| Country as Labeled | United States |
| Customer Reviews | 4.6 out of 5 stars 3,047 Reviews |
| Item Dimensions | 1.97 x 1.97 x 9.45 inches |
| Item Form | Cream |
| Item Volume | 500 Milliliters |
| Item Weight | 550 Grams |
| Item dimensions L x W x H | 1.97 x 1.97 x 9.45 inches |
| Manufacturer | E45 |
| Manufacturer Part Number | 285-3331 |
| Material Features | Lightweight |
| Material Type Free | Chemical Free |
| Model Name | E45 Dermatological Itch Relief Cream, Moisturising Dual Action Treatment for Itchy and Irritated Skin, 500g |
| Model Number | 348713 |
| Number of Items | 1 |
| Other Special Features of the Product | Travel Size |
| Product Benefits | Anti-itch,Moisturizing,Soothing |
| Recommended Uses For Product | Eczema |
| Scent Name | Cream |
| Skin Care Application Time | Anytime |
| Skin Type | Dry |
| Special Feature | Travel Size |
| Special Ingredients | Eucalyptus Oil |
| Specific Uses For Product | Eczema, allergy |
| Sun Protection | SPF 50 Sun Protection Factor (SPF) |
| Target Use Body Part | Skin |
| Unit Count | 17.64 Ounce |
W**S
IT REALLY WORKS’
HEAVEN in a bottle 🙌🏽🙌🏽🙌🏽🙌🏽 I have been suffering with eczema on both of my hands, of all places since June 2025 and I have literally tried EVERYTHING.. nothing works. Not even the prescribed medication. Long story short I read a post about E45 on Facebook about the same condition I have. Extreme itching, eczema. Yada Yada.. it hasn’t even been 24 hours. I could cry 😭 I know it’s pricey but it’s worth it!
H**A
Father in law approved
Bought this for my father in law bc he was itching like crazy!! I think he has excema but won't go get it checked out. He would itch until the point of bleeding. So a friend told me about this cream that helped her. I ordered it and low and behold it worked! He loves it so much the bottle is almost empty and I got it like 6 months ago. It was very effective for him and he stopped itching when he put it on. Will be buying again for him and also no more bleeding thank god!
P**S
Fantastic Lotion!
I've developed a mild eczema on my hands, arms and ankles and got a steroid cream prescription. When traveling home from England, Heathrow confiscated my steroid cream from my purse and forced me to put in my luggage even though a prescription label was clearly affixed to the tube. To try and cope on the flight, I bought a small tube of E45 Itch Relief at the airport drugstore, and was surprised at how it calmed down the red patches on my hands. I used up the tube at work over several months, and amazingly have now got down to using the steroid cream maybe once a month or so with a bad flare up. After reading how steroid cream can cause long term serious side effects, I combine this with a heavy Eucerin emollient on top at night. When the tube ran out, I bought this big 500g jar. I'm terrified to be without it as it has really reduced my use of the steroid cream.
C**W
contains a miracle ingredient
I am a 75 year old female who has been plagued with severe rashless overall body itch for years. It has kept me awake at night and caused extreme anxiety. Up until now the only product that helped was Cerave anti-itch lotion with pramoxine. This was somewhat soothing for an hour or so but not always. An article I read on itchy skin mentioned E45. I researched the ingredients, lauromacrogols and urea, and decided to take a chance. It is a miracle. I have been using it for five days, and in that time I have experienced longer and longer periods of total relief. If I wake in the night with a burning itch, an application of E45 gives me almost immediate relief. Whereas before I had to apply lotion every 3-4 hours 24 hours a day, now I can go with two daily applications about 12 hours apart. I am not saying this will work for everyone; nothing does. But for anyone who is desperate and has tried everything else, I would say give this a shot. It's expensive, but if it relieves the torment then it is cheap.
G**S
Not for sensitive skin.
Didn't work for me and left my skin burning.
P**.
Love
Amazing. Works wonders on my skin and I have severely dry skin and psoriasis.
K**E
Itch be gone!
Why is this wonderful stuff not available in the US? I was traveling in the UK and broke out in an eczema rash. The brands of lotion I usually buy were not available there, and the pharmacist/chemist recommended this so I bought it. I was dubious, but it worked wonders. It's not thick and filmy feeling like the eczema lotions I have used in the US, which I thought would be a downside in that I wouldn't get lasting itch relief and moisturizing. However, I was surprised that it could be light and relieve the itch for a good while. Also, it seemed to calm my skin so that it wasn't so red. Upon returning to the US, I bought this through amazon. It took a while to ship (which I understand is a common problem from the UK), but was so happy to get it when it arrived.
R**.
DISAPPOINTED
Did not help.
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